SYNTHESIS • CATALYSIS • MECHANISM
[37] The Enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
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W. C. Hartley, M. D. Greenhalgh, K. Kasten, T. Feoktistova, H. B. Wise, J. M. Laddusaw, A. B. Frost, S. Ng, A. M. Z. Slawin, B. E. Bode, P. H.-Y. Cheong, A. D. Smith.
[36] Lithiation-Functionalisation of Triazoles Bearing Electron-Withdrawing N-Substituents: Challenges and Solutions
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F. E. Bugden, G. J. Clarkson, M. D. Greenhalgh.*
[35] Stereoselective alkyl–alkyl cross-coupling
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M. D. Greenhalgh, S. P. Thomas.
[34] Scope, Limitations and Mechanistic Analysis of the HyperBTM-Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols
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S. M. Smith, M. D. Greenhalgh, T. Feoktistova, D. M. Walden, J. E. Taylor, D. B. Cordes, A. M. Z. Slawin, P. H.-Y. Cheong, A. D. Smith.
Eur. J. Org. Chem. 2022, 10.1002/ejoc.202101111
'Very Important Paper'
[33] Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to para-Quinone Methides
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J. N. Arokianathar, W. C. Hartley, C. McLaughlin, M. D. Greenhalgh, D. Stead, S. Ng, A. M. Z. Slawin, A. D. Smith.
[32] Horeau Amplification in the Sequential Acylative Kinetic Resolution of (±)-1,2-Diols and (±)-1,3-Diols in Flow
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A. Brandolese, M. D. Greenhalgh, T. Desrues, X. Liu, S. Qu, C. Bressy, A. D. Smith.
[31] Isothiourea-Catalyzed Synthesis of Pyrrole- and Indole-Functionalized Tetrasubstituted Pyridines
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S. Zhang, W. C. Hartley, M. D. Greenhalgh, S. Ng, A. M. Z. Slawin, A. D. Smith.
[30] TMEDA in Iron-Catalyzed Hydromagnesiation: Formation of Iron(II)-Alkyl Species for Controlled Reduction to Alkene-Stabilized Iron(0)
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P. G. N. Neate, M. D. Greenhalgh, W. W. Brennessel, S. P. Thomas, M. L. Neidig.
[29] Isothiourea-Catalyzed Acylative Kinetic Resolution of Tertiary α-Hydroxy Esters
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S. Qu, S. M. Smith, V. Laina-Martín, R. M. Neyyappadath, M. D. Greenhalgh, A. D. Smith.
Angew. Chem. Int. Ed. 2020, 59, 16572–16578
* Highlighted in Synfacts
[28] NHC-Catalyzed Enantioselective Synthesis of β-Trifluoromethyl-β-hydroxyamides
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A. T. Davies, M. D. Greenhalgh, A. M. Z. Slawin, A. D. Smith.
[27] Tandem Sequential Catalytic Enantioselective Synthesis of Highly-Functionalised Tetrahydroindolizine Derivatives
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S. Zhang, M. D. Greenhalgh, A. M. Z. Slawin, A. D. Smith.
Chem. Sci. 2020, 11, 3885–3892
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[26] Unanticipated Silyl Transfer in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis Using Silyl Nitronates
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A. Matviitsuk, M. D. Greenhalgh, J. E. Taylor, X. B. Nguyen, D. B. Cordes, A. M. Z. Slawin, D. W. Lupton, A. D. Smith.
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[25] Isothiourea-Catalysed Sequential Kinetic Resolution of Acyclic (±)-1,2-Diols
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S. Harrer, M. D. Greenhalgh, R. M. Neyyappadath, A. D. Smith.
[24] Mechanism of Bis(imino)pyridine Iron-Catalyzed Hydromagnesiation of Styrene Derivatives
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P. Neate, M. D. Greenhalgh, W. W. Brennessel, S. P. Thomas, M. L. Neidig.
[23] Catalytic Enantioselective Synthesis of Perfluoroalkyl-Substituted β-Lactones via a Concerted Asynchronous [2+2] Cycloaddition: A Synthetic and Computational Study
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D.-J. B. Antúnez, M. D. Greenhalgh, A. C. Brueckner, D. M. Walden, P. Elías-Rodríguez, P. Roberts, B. G. Young, T. H. West, A. M. Z. Slawin, P. H.-Y. Cheong, A. D. Smith.
[22] Synthesis of Fused Indoline-Cyclobutanone Derivatives via an Intramolecular [2+2] Cycloaddition
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R. M. Neyyappadath, M. D. Greenhalgh, D. B. Cordes, A. M. Z. Slawin, A. D. Smith.
Eur. J. Org. Chem. 2019, 5169–5174
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[21] Isothiourea-Catalyzed Regioselective Acylative Kinetic Resolution of Axially Chiral Biaryl Diols
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S. Qu, M. D. Greenhalgh, A. D. Smith.
Chem. Eur. J. 2019, 25, 2816–2823
'Hot Paper'
[20] Chiral Au(I)- and Au(III)-Isothiourea Complexes: Synthesis, Characterization and Application
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D. Gasperini, M. D. Greenhalgh, R. Imad, S. Siddiqui, A. Malik, F. Arshad, M. I. Choudhary, A. M. A. Al-Majid, D. B. Cordes, A. M. Z. Slawin, S. P. Nolan, A. D. Smith.
Chem. Eur. J. 2019, 25, 1064–1075
'Hot Paper'
[19] Evaluating Polymer-supported Isothiourea Catalysis in Industrially-preferable Solvents for the Acylative Kinetic Resolution of Secondary and Tertiary Heterocyclic Alcohols in Batch and Flow
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N. R. Guha, R. M. Neyyappadath, M. D. Greenhalgh, R. Chisholm, S. M. Smith, M. L. McEvoy, C. M. Young, C. Rodríguez-Escrich, M. A. Pericàs, G. Hähner, A. D. Smith.
[18] Best Practice Considerations for Using the Selectivity Factor, s, as a Metric for the Efficiency of Kinetic Resolutions
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M. D. Greenhalgh,* J. E. Taylor, A. D. Smith.
[17] Multiple Roles of Aryloxide Leaving Groups in Enantioselective Annulations Employing α,β-Unsaturated Acyl Ammonium Catalysis
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M. D. Greenhalgh, S. Qu, A. M. Z. Slawin, A. D. Smith.
[16] A C=O•••Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols
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M. D. Greenhalgh, S. M. Smith, D. M. Walden, J. E. Taylor, Z. Brice, E. R. T. Robinson, C. Fallan, D. B. Cordes, A. M. Z. Slawin, H. C. Richardson, M. A. Grove, P. H.-Y. Cheong, A. D. Smith.
[15] Acylative Kinetic Resolution of Alcohols Using a Recyclable Polymer-Supported Isothiourea Catalyst in Batch and Flow
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R. M. Neyyappadath, R. Chisholm, M. D. Greenhalgh, C. Rodríguez-Escrich, M. A. Pericàs, G. Hähner, A. D. Smith.
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[14] Aryloxide-Facilitated Catalyst Turnover in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis
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A. Matviitsuk, M. D. Greenhalgh, D.-J. B. Antúnez, A. M. Z. Slawin, A. D. Smith.
Angew. Chem. Int. Ed. 2017, 56, 12282–12287
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[13] Enantioselective N-Heterocyclic Carbene Catalyzed Formal [3+2] Cycloaddition Using α-Aroyloxyaldehydes and Oxaziridines
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R. W. F. Kerr, M. D. Greenhalgh, A. M. Z. Slawin, P. L. Arnold, A. D. Smith.
[12] Subtle Temperature-Induced Changes in Small Molecule Conformer Dynamics - Observed and Quantified by NOE Spectroscopy
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C. R. Jones, M. D. Greenhalgh, J. R. Bame, T. J. Simpson, R. J. Cox, J. W. Marshall, C. P. Butts.
[11] Non-Bonding 1,5-S•••O Interactions Govern Chemo- and Enantioselectivity in Isothiourea-Catalyzed Annulations of Benzazoles
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E. R. T. Robinson, D. M. Walden, C. Fallan, M. D. Greenhalgh, P. H.-Y. Cheong, A. D. Smith.
[10] Enantioselective Synthesis of 2,3-Disubstituted trans-2,3-Dihydrobenzofurans Using a Brønsted Base/Thiourea Bifunctional Catalyst
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D.-J. B. Antúnez, M. D. Greenhalgh, C. Fallan, A. M. Z. Slawin, A. D. Smith.
[9] Iron-Catalysed Hydrofunctionalisation of Alkenes and Alkynes
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M. D. Greenhalgh, A. S. Jones, S. P. Thomas.
[8] Broad Scope Hydrofunctionalization of Styrene Derivatives Using Iron-Catalyzed Hydromagnesiation
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A. S. Jones, J. F. Paliga, M. D. Greenhalgh, J. M. Quibell, A. Steven, S. P. Thomas.
Org. Lett. 2014, 16, 5964−5967
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[7] Iron-Catalysed Hydromagnesiation: Synthesis and Characterisation of Benzylic Grignard Reagent Intermediate and Application in the Synthesis of Ibuprofen
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M. D. Greenhalgh, A. Kolodziej, F. Sinclair, S. P. Thomas.
[6] Iron-Catalysed Reductive Cross-Coupling of Alkenes
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M. D. Greenhalgh, S. P. Thomas.
[5] Iron-Catalysed Chemo-, Regio-, and Stereoselective Hydrosilylation of Alkenes and Alkynes Using a Bench-Stable Iron(II) Pre-Catalyst
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M. D. Greenhalgh, D. J. Frank, S. P. Thomas.
[4] Chemo-, Regio-, and Stereoselective Iron-Catalysed Hydroboration of Alkenes and Alkynes
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M. D. Greenhalgh, S. P. Thomas.
[3] Iron-Catalyzed Hydromagnesiation of Olefins
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M. D. Greenhalgh, S. P. Thomas.
[2] Iron-Catalyzed, Highly Regioselective Synthesis of α-Aryl Carboxylic Acids from Styrene Derivatives and CO2
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M. D. Greenhalgh, S. P. Thomas.
J. Am. Chem. Soc. 2012, 134, 11900–11903
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* Highlighted on Organic Chemistry Portal
[1] Iron-Catalysed, Hydride-Mediated Reductive Cross-Coupling of Vinyl Halides and Grignard Reagents
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B. A. F. Le Bailly, M. D. Greenhalgh, S. P. Thomas.